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KMID : 0391520150230030148
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Journal of the Korean Child Neurology Society
2015 Volume.23 No. 3 p.148 ~ p.151
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A Case of Kikuchi-Fujimoto Disease associated with Aseptic Meningitis and Cerebellitis
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Ryu Ji-Eun
Park Hye-Rim
Lee Eun-Hye
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Abstract
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Histiocytic necrotizing lymphadenitis (HNL) or Kikuchi-Fujimoto disease are a rare,
self-limited lymphadenopathy accompanied by fever and various extranodal manifestations.
Although neurological complications occasionally occur in HNL, cerebellar
symptoms are very rare. Here we report a 15-year-old male patient who was admitted
to Kyung Hee University College of Medicine complaining of headache, fever,
and axillary lymph node enlargement. The patient did not respond to antibiotics.
We performed excisional biopsies on the involved lymph nodes. We diagnosed HNL
and the patient initially seemed to recover. However, the headache and fever then
worsened and he developed diplopia, ataxia, and action tremor on the 5th hospital
day. An action tremor was evident on conducting the finger to nose test, he failed
the Romberg test and tandem gait. Cerebrospinal fluid pleocytosis and an elevated
protein level were noted. Viral and tuberculosis markers in serum and cerebrospinal
fluid were all negative. We diagnosed him as having HNL accompanied by aseptic
meningitis and cerebellitis, which were suspected to be associated with an immunemediated
mechanism.
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KEYWORD
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Histiocytic Necrotizing Lymphadenitis, Meningitis, Aseptic
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